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Breakthrough in London: Doctors successfully cure blindness in children born with a genetic condition in world first
February 22, 2025
03:04
In a groundbreaking medical achievement, British doctors have become the first in the world to cure blindness in children born with a rare genetic condition through pioneering gene therapy. The successful treatment at London’s Great Ormond Street Hospital marks a watershed moment in treating genetic vision disorders.
The treatment targets leber congenital amaurosis (LCA), a severe form of retinal dystrophy that causes blindness from birth due to a defect in the AIPL1 gene. Using an innovative approach, doctors performed keyhole surgery to inject healthy copies of the AIPL1 gene directly into the retina, with the procedure taking just one hour.
The outcomes have been transformative for the four children treated, aged between one and two years. Post-treatment, these young patients can now:
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The treatment group included children from the United States, Turkey, and Tunisia, who were carefully selected by specialists from Moorfields Eye Hospital and UCL in 2020. The five-year observation period’s results were recently published in the prestigious Lancet journal.
Professor Michel Michaelides, a consultant retinal specialist at Moorfields Eye Hospital and professor of ophthalmology at the UCL Institute of Ophthalmology, expressed great optimism about the results. “We have, for the first time, an effective treatment for the most severe form of childhood blindness, and a potential paradigm shift to treatment at the earliest stages of the disease,” he told The Guardian.
Professor James Bainbridge, consultant retinal surgeon at Moorfields and professor of retinal studies at UCL Institute of Ophthalmology, highlighted the significance of the outcomes. He explained that children born with LCA typically can only distinguish between light and dark, with what little sight they have deteriorating within years of birth. “Some children are even able to read and write following the intervention which is something that one would absolutely not expect in this condition, untreated,” he noted.
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The innovative procedure was conducted with careful consideration for patient safety:
This breakthrough represents a significant advance in treating genetic vision disorders and offers hope to families affected by LCA worldwide. The success of this treatment could pave the way for similar gene therapy approaches in treating other genetic conditions affecting vision.
This article Breakthrough in London: Doctors successfully cure blindness in children born with a genetic condition in world first appeared first on BreezyScroll.
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